Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique
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Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique.
BACKGROUND Organic dusts may cause inflammation in the airways. This study was performed to assess the usefulness of the induced sputum technique for evaluating the presence of airways inflammation using inhaled endotoxin (lipopolysaccharide) as the inducer of inflammation. METHODS To characterise the inflammatory response after inhalation of endotoxin, 21 healthy subjects inhaled 40 microgra...
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The ability of bacterial endotoxins to produce local inflammation has been recognized as one of the many biologic activities of these intriguing products of the gram-negative bacterial cell.1" This property of endotoxin, however, has not been studied extensively with the highly purified materials now available. Preliminary observations are reported here on the inflammatory response elicited by ...
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A potential risk for workers exposed to inhalation of endotoxin, as well as the primary tissue changes, is the possibility of subsequent development of adult respiratory distress syndrome. Accordingly, hamsters were administered one hour aerosols of Enterobacter agglomerans and allowed to rest for six hours to produce maximum microlesions in the lung. One hour before this peak, the animals were...
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• Previous studies in this laboratory have indicated that a combination of systemic hypercoagulability and retarded blood flow is capable of producing a red thrombus in the veins of animals. The hypothesis has been proposed that activation of the procoagulants involved in the formation of intrinsic thromboplastin produces massive thrombosis in large vessels in areas of markedly reduced blood fl...
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BACKGROUND The aim of this study was to establish the sputum inflammatory profile and changes in levels of leukotriene B₄ (LTB₄) and a panel of Th1/Th2 cytokines in subjects with suspected occupational asthma (OA) following specific inhalation challenge (SIC) to high-molecular-weight (HMW) and low-molecular-weight (LMW) agents. MATERIAL AND METHODS Fifty-one consecutive subjects undergoing SI...
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ژورنال
عنوان ژورنال: Thorax
سال: 1998
ISSN: 0040-6376
DOI: 10.1136/thx.53.12.1047